Christine saccani biography

  • Christine saccani biography.
  • Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes.
  • Christine was recognized with the NASA Early Career Achievement Medal and the Rising Star Award from the NASA Office of the General Counsel.

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    . Author manuscript; available in PMC: Sep

    Published in final edited form as: Circ Res. Sep 15;(7)– doi: /CIRCRESAHA

    Abstract

    Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes, and a non-dilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetric with the most severe hypertrophy involving the basal interventricular septum. Left ventricular outflow tract obstruction is present at rest in about one third of the patients, and can be provoked in another third. The histologic features of HCM include myocyte hypertrophy and disarray, as well as interstitial fibrosis. The hypertrophy is also frequently associated with left ventricular diastolic dysfunction.

    In the majority of patients, HCM has a relatively benign course. However, HCM is also an important cause of sudden cardiac death, particularly in adolescents and young adults. Nonsustained ventricular ta

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    Jourdan K Ewoldt

    Jourdan K Ewoldt

    1Department of Biomedical Engineering, Boston University, Boston, MA , USA.

    Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing - original draft, Writing - review & editing

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    1, Miranda C Wang

    Miranda C Wang

    1Department of Biomedical Engineering, Boston University, Boston, MA , USA.

    2Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA , USA.

    3Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA , USA.

    Formal analysis, Investigation, Resources, Validation, Writing - review & editing

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    1,2,3, Micheal A McLellan

    Micheal A McLellan

    1Department of Biomedical Engineering, Boston University, Boston, MA , USA.

    2Wyss Institute for Biologica

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