Horan h hohlfeld biography definition
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From the biology of PP2A to the PADs for therapy of hematologic malignancies
Introduction
The phosphorylation status of proteins is crucial in regulating their functions and properties. In normal cells, kinases and phosphatases participate to phosphorylation processes (1). By modulating the phosphorylated load, they control the on–off switch of target proteins. The balance between kinase and phosphatase activities is critical in many hematological malignancies. Although numerous studies highlighted the role of kinases in malignant transformation, much less is known about the contribution of specific phosphatases to cancer development.
Oncogenic kinases and tumor-suppressor phosphatases maintain the cell homeostasis by exerting their activities on cell growth, survival, and differentiation. Thus, aberrant oncogene expression and loss of tumor-suppressor gene function affect cell cycle, apoptosis, and DNA damage repair machineries. ABL1 is a well-characterized kinase that
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Published in final edited form as: Brain Behav Immun. 2011 Apr 30;25(6):1264–1271. doi: 10.1016/j.bbi.2011.04.017
Abstract
Objective
To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD).
Methods
Serum BDNF concentrations were assayed by ELISA and fitness was assessed using a standardized exercise stress test. The Mini Mental Status Examination (MMSE), California Verbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.
Results
In subjects with CAD (n = 88; 85.2% male, mean age 62.8 ± 10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations ( • Long-term high blood pressure in the arteries This article is about arterial hypertension. For other forms of hypertension, see Hypertension (disambiguation). Medical conditionHypertension
Hypertension Other names Arterial hypertension, high blood pressure Automated ledd blood pressure meter showing arterial hypertension (shown bygd a systolic blood pressure 158 mmHg, diastolic blood pressure 99 mmHg and heart rate of 80 beats per minute) Specialty Cardiology, Nephrology Symptoms None[1] Complications Coronary artery disease, stroke, heart failure, peripheral arterial disease, vision loss, chronic kidney disease, dementia[2][3][4] Causes Usually lifestyle and genetic factors[5] Risk factors Lack of sleep, excess salt, excess body vikt, smoking, alcohol[1][5] Diagnostic method Resting blood pressure in adults
≥ 130/80 mmHg[6] or ≥ 140/